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Submission Preparation Checklist

As part of the submission process, authors are required to check off their submission's compliance with all of the following items, and submissions may be returned to authors that do not adhere to these guidelines.
  • The submission has not been previously published, nor is it before another journal for consideration. The submission file is in Microsoft Word file format. The text adheres to the stylistic and bibliographic requirements outlined in the Author Guidelines.

Author Guidelines

Author Guidelines

We thrive to publish high-quality, evidence-based reviews to provide a comprehensive and up-to-date overview of a specific topic within the field of medicine. Written by experts on emerging topics, each published review follows strict methodological guidelines that ensure its reproducibility with high reliability. The following article types are considered in HYMR: Systematic reviews with or without meta-analysis, Narrative reviews, Rapid reviews, Short reports, and editorials. In addition, high-quality peer reviews that might benefit a wider audience than just the article's authors can be curated and offered to be published.

Authors can submit unsolicited reviews and articles. However, we encourage prospective authors to check "High Yield Topics": Add Link representing well-curated topics in the interest of practicing physicians and working researchers. If you wish to submit your article to one of these topics, choose the respective topic from the categories at the beginning of the submission process. Moreover, authors are encouraged to submit methodological advanced (e.g., describing new analysis or reporting methods or scoring system), where such articles can be either submitted as short reports or reviews, depending on their content.


Below are briefs on the author guidelines we follow in High Yield Reviews. We generally adopt the latest guidelines in the American Medical Association (AMA) guide. We also adhere to the ICMJE Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly Work in Medical Journals.

We advise authors to visit High Yield Med Academy to learn more about doing high-quality reviews.

Mandatory submission components include a cover letter and the manuscript file:

Cover letter: Should include complete information of all authors, including full names, highest academic degrees, affiliations, and emails of all authors; name and complete contact information for the corresponding author (affiliation, postal/mail address, email address, and telephone number); and any conflict of interest to disclose. Even if no conflict of interest is present, you should state that explicitly on the title page "The authors declare that they have no competing interests". In addition, acknowledgments or financial support should also be mentioned here.

Please note that we operate a double-blind peer review. So, all identifying information should be only in the cover letter.

Manuscript Components: Include in the manuscript file a title, abstract, text, references, and as appropriate, figure legends and tables. Start each of these sections on a new page, numbered consecutively, beginning with the title page. Figures should be submitted as separate files (1 file per figure) and not included in the manuscript text. It should be in word format.


All types of manuscripts should consist of the following, without including any author-identifying information:

Title Page: The title page should be the first page of your manuscript file. It should include a manuscript title and a short title. No author details should be included here.

Abstracts: structures with up to 250 words, with introduction, methods, results, and conclusion sections.

Keywords: four to six keywords.

Text: Depend on the manuscript type as follows:

- Systematic review with or without meta-analysis: Can be performed with or without a meta-analysis. Manuscripts should typically include an introduction, methods, results, and discussion sections. Should adhere and explicitly state the adherence with PRISMA guidelines.

- Methodology article or Protocol for a systematic review: Methodology and protocol articles will only be considered for proposed or ongoing research that has not yet submitted the final data of the article at the time of submission, and should provide a detailed account of the hypothesis, rationale, and methodology of the study. Such methodology articles or protocols should have an overview of the topic, a detailed methodology that permits high reproducibility, a brief discussion of potential implications. No result section is required in such an article type. 

- Narrative review (aka., reviews): Typically begins with an introduction. Other sections are optional (i.e., methods, results, and discussion). Review sections are expected to be customized to the topic of interest.

- Rapid review manuscripts should typically include an introduction, methods, results, and discussion sections. Manuscripts are typically reviewed more quickly than traditional research articles, and authors should expect a faster turnaround time for both review and publication. Rapid reviews are generally used to update current evidence or to provide new evidence on an existing topic. However, this should not compromise the quality of its methodology.

- Research articles: Are used to report primary data that are of interest to journal readers. Original primary research relating to the design, conduct, or reporting of systematic reviews is the primary focus of such research articles. Should follow a similar introduction, methods, results, and discussion sections. We encourage authors to ensure that their datasets are either deposited in publicly available repositories (where available and appropriate) or presented in the main manuscript or additional supporting files whenever possible.

The journal also publishes editorials that are written by or solicited by editors.

The methods section for the systematic reviews, systematic reviews with meta-analysis, or protocols should include: the aim, design, and setting of the study the characteristics of participants or description of materials a clear description of all processes, interventions, and comparisons, the type of statistical analysis used, including a power calculation if appropriate.


Consider the following guidelines for your submission:

Tables and figures

Text formatting guidelines for tables

  • Number all tables in the order of their citation in the text.
  • Include a brief title for each table without using abbreviations.
  • Use only separate cells, ordered lists, or unordered lists to separate content within the
    same cell into individual lines. Do not use spaces, tabs, html tags, or manual line breaks
    inside a table.
  • Symbols indicating statistical significance should appear in the same cell as the value
    and should not have their own column.
  • To highlight individual values in tables, you may use boldface type, italic type, or a single
    color of shading (note: the shading color is standardized so will not exactly match what
    you provide). Do not use multiple colors of shading, underlining, or font size to highlight
    values in tables. Do not use color to indicate meaning.
  • Text color is limited to black.
  • Large tables that extend to more than one page are discouraged and should be supplied as supplementary material when necessary.


  • Number all figures in the order of their citation in the text.
  • Include a brief title for each figure without using abbreviations.
  • Include all figure legends at the end of the manuscript file.
  • Submit figures separately without embedding them in the main manuscript.
  • Make sure to submit high-quality figures in image formats (e.g., PNG, JPEG ...), or pdf. If the figure represents graphs, word formats can be submitted. 
  • All figures should be supplied with at least 300dpi for the best resolution in the published article.
  • All symbols, indicators (including error bars), line styles, colors, and abbreviations should be defined in a legend.
  • Each axis on a statistical graph must have a label and units of measure should be labeled.

Please note that it is the responsibility of the author(s) to obtain permission from the copyright holder to reproduce figures (or tables) that have previously been published elsewhere. In order for all figures to be open access, authors must have permission from the rights holder if they wish to include images that have been published elsewhere in non-open access journals. Permission should be indicated in the figure legend, and the original source included in the reference list.

Optional: Figure quality can be assessed using PACE service.

Supplementary material

As the length and quantity of data are not restricted to many article types, authors can provide datasets, images, tables, video, or other documents/files as supplementary material. Any supplementary material files that are associated with an article must be submitted with the article. This applies to all files made available in the article record, even if the files are also available in a public repository. An exception may be made for files that require custom software to read/use or that are very large (over 2GB).

Do not include files such as patient consent forms, certificates of language editing, or revised versions of the main manuscript document with tracked changes. Such files are only provided upon editor's request and should be sent by email to the journal’s editorial email address, quoting the manuscript reference number. 


Authors are responsible for the accuracy and completeness of their references and for correct text citations. Number references in the order they appear in the text. In text, tables, and legends, identify references with superscript Arabic numerals. When listing references, follow AMA style. List all authors and/or editors up to 6; if more than 6, list the first 3 followed by "et al." Note: Journal references should include the issue number in parentheses after the volume number.

References in systematic reviews that were included during the full-text screening and included for data extraction can be cited in the main manuscript or the supplementary material (if they were too many).

Here are some examples of how to reference different types of sources using AMA style:

  • Journal article: Smith J, Johnson M, Williams D, et al. The effects of exercise on blood pressure. Am J Cardiol. 2020;105(6):789-795.
  • Book: Jones B. Nutrition for Health and Wellness. 2nd ed. New York, NY: McGraw-Hill; 2020.
  • Website: World Health Organization. COVID-19. Geneva, Switzerland: World Health Organization; 2020. Available from the WHO website

Each reference should be cited in the text using superscript Arabic numerals. These superscript numbers should be outside periods and commas but inside colons and semicolons. Multiple references may be cited in the same instance. If you are citing sequential references, these should be indicated with a hyphen. More references and details can be found AMA Manual of Style.


Generic drug names should generally be used. When proprietary brands are used in research, include the brand names in parentheses.

Do not use abbreviations in the title or abstract and limit their use in the text. Expand all abbreviations at first mention in the text. 


Authorship criteria

Authorship should be agreed upon at the beginning of any project. Any author included in the author list should have contributed significantly to the paper, and no person who has made a significant contribution should be omitted from the list of authors. Significant contributions include, but are not limited to the criteria for authorship suggested by ICMJE:

  • conception or design of the study
  • acquisition, analysis, or interpretation of data
  • writing (original draft or revision for important intellectual content)
  • supervision and/or final approval of the version to be submitted.

Acknowledgments may be used to denote contributions to the work that do not meet the criteria of authorship such as supporting the study, general mentoring, collecting data, acting as study coordinator, and other related activities

Any author's dispute should be optimally solved through institutional guidance. The following scoring system “Authorship Determination Scorecard” can help solve disputes through quantitative assessment of contributions:

For further details about authorship, please refer to COPE discussion document on authorship:

No authors will be added or removed post-submission unless the journal editor and all co-authors are informed and in agreement with this change. 

The use of artificial intelligence in the diagnosis of (Diseases)

This section will publish reviews and articles that assesses and discusses the diagnostic accuracy of artificial intelligence (AI) models implemented in the diagnosis and assessment of different diseases in different medical specialties.

Please check the corresponding section in High Yield Topics for more details and guidance on this topic: Add link

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